New research indicates that people who discontinue blockbuster weight-loss injections like semaglutide or tirzepatide can put back on reduced body mass far faster than those who end conventional lifestyle regimens.
Findings released in a major medical journal shows that while obese individuals often shed substantial amounts of their total mass while on the medication, the weight is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"People using such treatments must be aware of the potential of fast rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
Such speed of regain implies a return to pre-treatment mass within about one and a half years.
Comparing Approaches
The study, which looked at dozens of trials involving over 9,000 of patients, contrasted the results of the injectable medications with other pills.
Scientists emphasize that people who lose weight through dieting generally have a slower creep back—approximately 0.1 kg a month—after stopping.
Understanding the Rapid Regain
Doctors propose the mechanism of the drugs is key to understanding the accelerated regain.
The injections mimic a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production might result in the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication means appetite is unsuppressed, making excessive eating much more probable."
A Lifelong Condition?
Health authorities advise the jabs for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Professionals contend that, considering the high risk of weight regain, the treatment should be considered ongoing.
This opinion is supported by drug manufacturers, who say that the results "emphasize the chronic nature of excess weight," akin to managing diseases like hypertension.
User Accounts
Users who have come off the jabs describe a intense resurgence of hunger.
"I experienced something flipping and you're instantly starving," described an individual.
This challenge is compounded if individuals have not established sustainable dietary or behavioural changes during treatment.
Significant Adoption
Figures suggest that a significant number of people in the UK have tried these injections in the last 12 months, with desire being substantial.
- Use is greater among women than males.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion obtain the medications through private prescriptions rather than public health services.
Ultimately, experts caution that while the jabs are effective tools for weight loss, they are not a standalone cure and long-term success relies on ongoing lifestyle management.
